Search results for " DMA"

Long-term anti-tumour necrosis factor therapy reverses the progression of carotid intima–media thickness in female patients with active rheumatoid ar…

2009

The objective of the study is to evaluate the effect of TNF inhibition on carotid thickness over a 2-year period. 144 women with RA diagnosed according to ACR criteria, without clinical evidence of cardiac and/or vascular disease were enrolled and compared with 78 matched controls. All patients received methotrexate (15–20 mg weekly) for 3 months. Responders (n = 79) continued to be treated with methotrexate, non-responders (n = 40) moved to methotrexate plus a TNF alpha antagonist. Echosonographic studies of carotids were obtained before and after 2-year follow-up. A significant decrease of ca-IMT was observed in anti-TNF-treated patients (P < 0.001); on the other hand, no significant vari…

Hirālu piridīna organokatalizatoru izstrāde un pielietojums

2015

Maģistra darba ietvaros tika izstrādāta hirālu DMAP organokatalizatoru sintēze. Iegūto organokatalizatoru aktivitāte tika pārbaudīta tetrazola hemiaminālu dinamiskajā kinētiskajā sadalīšanā.

Diatom species composition and indices for determining the ecological status of coastal Mediterranean Spanish lakes

2013

Diatom indices have been used and tested mainly for assessing the ecological status of rivers and deep lakes, but there are scarce studies that determine their effectiveness in shallow lakes and in coastal Mediterranean lakes. This study evaluates the validity of several common diatom indices (SPI, BDI, CEC and TDIL) for the determination of the ecological quality of three coastal lakes (Valencia, Spain) and presents descriptions and ecological data of the main diatom species recorded. Diatom samples were collected from phytobenthos, both from epiphyton of the dominant submerged macrophytes and the sediment. The ecological status of the systems was determined according to different physico-…

Halloysite nanotubes as sustainable nanofiller for paper consolidation and protection

2014

We investigated the filling process of cellulose-based paper with natural clay nanotubes and their mixtures with hydroxypropyl cellulose (HPC) that is commonly used as glue and consolidant for degraded paper. A comprehensive characterization of the materials was carried out through morphology, wettability, thermal degradation, and tensile properties. The treatment with halloysite nanotubes generated a decrease of the paper mechanical performance and did not alter the thermal properties. The co-presence of HPC and nanoparticles generated a more uniform nanotubes distribution in the paper fibrous structure and a significant enhancement of both the mechanical properties and the surface hydroph…

The cytotoxic effect exerted by parthenolide and DMAPT on breast cancer stem-like cells

2015

Triple-negative breast cancers (TNBCs) are aggressive forms of breast carcinoma associated with a high rate of recidivism. It is known that a small proportion of tumour cells, termed cancer stem cells (CSCs), is responsible for tumour formation, progression and recurrence. The sesquiterpene lactone parthenolide (PN) was identified as the first small molecule capable of killing CSCs.1 Previously we have shown2 that PN and its soluble analogue DMAPT induce a strong cytotoxic effect in MDA-MB231 cells, the most studied line of TNBCs. In the present research we investigated about the effects exerted by both PN and DMAPT on breast cancer stem-like cells derived from three lines of TNBCs (MDA-MB2…

Evaluation of the in vitro and in vivo antineoplastic effects of Parthenolide on MDA-MB231 breast cancer cells

2012

Triple-negative breast cancer refers to an aggressive subtype of breast cancer in which the tumor cells lack receptors for estrogen, progesterone and the HER2 protein on their surfaces. This type of breast cancer does not respond to treatments such as hormone therapy, like tamoxifen and aromatase inhibitors, or drugs that target HER2, like Herceptin. It is important, therefore, the identification of new selective drugs for the treatment of these tumors. Parthenolide (PN), a sesquiterpene lactone extracted from the medical plant Tanacetum parthenium, exerts anticancer activity on several tumor cell lines in culture, acting through diverse molecular mechanisms. Our previous studies have shown…

Combined treatment of caffeic acid and DMAPT induces AMPK dependent death in MDA-MB231 cells

EFFECT OF PROCESSING TEMPERATURE VARIATION ON STORAGE STABILITY OF TIRE RUBBER MODIFIED BINDERS

2012

Tire Rubber Modified Binders (TR-MBs), produced through wet process and used worldwide (e.g. asphalt rubber), have been demonstrated to provide various benefits to pavements and, moreover, represent a good opportunity for recycling tire rubber. However, this technology is still struggling to be fully adopted in Europe, mainly because of the poor stability of TR-MBs during high temperature storage, which leads to high initial costs in modifying existing asphalt plants. No-agitation TR-MBs (also known as terminal blends) are proving to be a great option and their development could also be the key to spreading the use of tire rubber in paving applications in Europe. This paper aims to enrich t…

Comparison between various bituminous binders modified with crumb tyre rubber

2009

The aim of this paper is to show how the rheology, the performance and the storage stability of different bituminous binders, obtained from two bitumens with different asphaltenes content, change their properties when they are modified with recycled tyre crumb rubber. Physical, chemical and performance characterisation followed by rheological and storage stability analyses have been undertaken as the basis for the comparison. The results of the investigation indicate that bitumen with lower asphaltenes content is more influenced by the modification with the rubber. However, the modification of the bitumen with the higher asphaltenes content gives a binder with better performance and storage…